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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621 Species: Homo sapiens RGD Object: Gene Symbol: CXCL2 Name: chemokine (C-X-C motif) ligand 2

Acc ID: CHEBI:9130 Term: sevoflurane Definition: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups. CasRN: 28523-86-6 Chemical ID: MESH:C009250

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:70069	6480464	CTD	sevoflurane results in decreased expression of CXCL2 mRNA	PMID:15564938
increases expression	ISO	RGD:70069	6480464	CTD	sevoflurane results in increased expression of CXCL2 mRNA	PMID:10422944