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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:9123
Term: sertraline
Definition: A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.
Chemical ID: MESH:D020280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3increases expressionISOEIF2AK3 (Homo sapiens)6480464CTDSertraline results in increased expression of EIF2AK3 mRNAPMID:24865413
Eif2ak3multiple interactionsISOEIF2AK3 (Homo sapiens)6480464CTDMAP4K4 mutant form inhibits the reaction [Sertraline results in increased phosphorylation of EIF2AK3 protein]; Sertraline results in increased expression of and results in increased phosphorylation of EIF2AK3 proteinPMID:24865413
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