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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; SB 203580 inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]PMID:17640564 PMID:30928397 PMID:31790703
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Quercetin affects the localization of NFE2L2 protein]]; [SB 203580 co-treated with Cycloheximide] inhibits the reaction [Quercetin results in decreased expression of NFE2L2 protein]; [SB 203580 co-treated with Quercetin] results in increased expression of NFE2L2 protein; Cycloheximide inhibits the reaction [[SB 203580 co-treated with Quercetin] results in increased expression of NFE2L2 protein]; Cycloheximide inhibits the reaction [SB 203580 affects the reaction [Quercetin affects the localization of NFE2L2 protein]]; SB 203580 affects the reaction [Quercetin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [gallium nitrate results in increased activity of NFE2L2 protein]; SB 203580 inhibits the reaction [Quercetin affects the localization of and results in increased activity of NFE2L2 protein]; SB 203580 inhibits the reaction [Quercetin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Quercetin results in decreased expression of NFE2L2 protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin affects the localization of NFE2L2 protein]]PMID:17433488 PMID:18586083 PMID:22197970 PMID:27454768
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDSB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; SB 203580 affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; SB 203580 inhibits the reaction [farrerol affects the localization of NFE2L2 protein]; SB 203580 promotes the reaction [[Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein]PMID:22488045 PMID:25449124 PMID:26111761 PMID:30742845 PMID:31029725
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