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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Thra
Name: thyroid hormone receptor alpha
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thraincreases expressionISOThra (Mus musculus)6480464CTDpyrazolanthrone results in increased expression of THRA mRNA alternative formPMID:17641275
Thramultiple interactionsISOThra (Mus musculus)6480464CTD[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; IL1B protein inhibits the reaction [pyrazolanthrone results in increased expression of THRA mRNA alternative form]PMID:17641275
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