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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of and affects the localization of STAT3 protein]PMID:27174766
Stat3increases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDpyrazolanthrone results in increased phosphorylation of STAT3 proteinPMID:33030807
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]PMID:19429262 PMID:22696236 PMID:24349194 PMID:30871965 PMID:33030807
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