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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
Acc ID: CHEBI:90225
Term: rubitecan
Definition: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Chemical ID: MESH:C079905
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1increases expressionISOAIFM1 (Homo sapiens)6480464CTDrubitecan results in increased expression of AIFM1 proteinPMID:21695227
Aifm1multiple interactionsISOAIFM1 (Homo sapiens)6480464CTD[rubitecan co-treated with Phosphatidylcholines] results in increased expression of AIFM1 proteinPMID:21695227
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