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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353354
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNQ1
Name: potassium voltage-gated channel subfamily Q member 1
Acc ID: CHEBI:8890
Term: (S)-ropivacaine
Definition: A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.
Chemical ID: MESH:C037663
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNQ1decreases activityEXP 6480464CTDRopivacaine results in decreased activity of KCNQ1 proteinPMID:16931984
KCNQ1multiple interactionsEXP 6480464CTDRopivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]PMID:16931984
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