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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:88212
Term: lead(II) chloride
Definition: An inorganic chloride consisting of two chlorine atoms covalently bound to a central lead atom.
Chemical ID: MESH:C029891
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects response to substanceISOESR1 (Homo sapiens)6480464CTDESR1 protein affects the susceptibility to lead chloridePMID:12746304
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDlead chloride results in decreased expression of ESR1 mRNA; lead chloride results in decreased expression of ESR1 proteinPMID:12746304
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDlead chloride results in increased activity of ESR1 proteinPMID:12746304
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDEstradiol promotes the reaction [lead chloride results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [lead chloride results in decreased expression of ESR1 protein]; lead chloride inhibits the reaction [Estradiol binds to ESR1 protein]; lead chloride promotes the reaction [Estradiol results in decreased expression of ESR1 protein]PMID:12746304
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