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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2977 Species: Rattus norvegicus RGD Object: Gene Symbol: Klrc2 Name: killer cell lectin-like receptor subfamily C, member 2

Acc ID: CHEBI:8772 Term: raloxifene Definition: A benzothiophene that has formula C28H27NO4S. CasRN: 84449-90-1 Chemical ID: MESH:D020849

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1349370	6480464	CTD	ESR1 protein affects the reaction [Raloxifene results in increased expression of KLRC2 mRNA] ESR2 protein affects the reaction [Raloxifene results in decreased expression of KLRC2 mRNA]	PMID:14699072
affects expression	ISO	RGD:1349370	6480464	CTD	Raloxifene affects the expression of KLRC2 mRNA	PMID:14699072
multiple interactions	ISO	RGD:1349370	6480464	CTD	[Raloxifene co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA	PMID:19059307