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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects bindingISOAhr (Mus musculus)6480464CTDRaloxifene Hydrochloride binds to AHR proteinPMID:24481452
Ahraffects localizationISOAhr (Mus musculus)6480464CTDRaloxifene Hydrochloride affects the localization of AHR proteinPMID:24481452
Ahraffects localizationISOAHR (Homo sapiens)6480464CTDRaloxifene Hydrochloride affects the localization of AHR proteinPMID:24481452
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTDRaloxifene Hydrochloride inhibits the reaction [Methylcholanthrene binds to AHR protein]PMID:24481452
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTD[Raloxifene Hydrochloride results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNAPMID:19901195
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