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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586165
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kmt2a
Name: lysine methyltransferase 2A
Acc ID: CHEBI:8687
Term: pyrvinium
Definition: A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.
Chemical ID: MESH:C024631
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kmt2amultiple interactionsISOKmt2a (Mus musculus)6480464CTDpyrvinium inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib]PMID:26367796
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