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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872 Species: Homo sapiens RGD Object: Gene Symbol: SOD2 Name: superoxide dismutase 2, mitochondrial

Acc ID: CHEBI:8630 Term: pterostilbene Definition: A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'. CasRN: 537-42-8 Chemical ID: MESH:C107773

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]	PMID:18852136
increases expression	EXP		6480464	CTD	pterostilbene results in increased expression of SOD2 mRNA	PMID:22450950
increases activity	EXP		6480464	CTD	pterostilbene results in increased activity of SOD2 protein	PMID:22450950 PMID:22572619
increases activity	EXP		6480464	CTD	pterostilbene results in increased activity of SOD2 protein	PMID:22572619 PMID:22450950