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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:8630
Term: pterostilbene
Definition: A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.
Chemical ID: MESH:C107773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDpterostilbene results in increased activity of CASP9 proteinPMID:25341683
Casp9increases cleavageISOCasp9 (Mus musculus)6480464CTDpterostilbene results in increased cleavage of CASP9 proteinPMID:20681671
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDpterostilbene results in increased expression of CASP9 proteinPMID:20152895
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDpterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP9 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP9 protein]PMID:25341683 PMID:33930484
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