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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:8502
Term: 6-propyl-2-thiouracil
Definition: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.
Chemical ID: MESH:D011441
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaaffects expressionEXP 6480464CTDPropylthiouracil affects the expression of VEGFA proteinPMID:25499719
Vegfadecreases expressionEXP 6480464CTDPropylthiouracil results in decreased expression of VEGFA mRNA; Propylthiouracil results in decreased expression of VEGFA proteinPMID:24780913 PMID:25298361 PMID:25499719 PMID:33150595
Vegfaincreases expressionEXP 6480464CTDPropylthiouracil results in increased expression of VEGFA mRNA; Propylthiouracil results in increased expression of VEGFA proteinPMID:30047161 PMID:35101570 PMID:37295576
Vegfaincreases methylationEXP 6480464CTDPropylthiouracil results in increased methylation of VEGFA promoterPMID:33150595
Vegfamultiple interactionsEXP 6480464CTDhaizao yuhu inhibits the reaction [Propylthiouracil results in increased expression of VEGFA mRNA]; haizao yuhu inhibits the reaction [Propylthiouracil results in increased expression of VEGFA protein]; Thyroxine inhibits the reaction [Propylthiouracil results in increased expression of VEGFA protein]; xiaoluowan inhibits the reaction [Propylthiouracil results in increased expression of VEGFA protein]PMID:35101570 PMID:37295576
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