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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:8499
Term: propranolol
Definition: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Chemical ID: MESH:D011433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDPropranolol results in decreased expression of MMP9; Propranolol results in decreased expression of MMP9 mRNA; Propranolol results in decreased expression of MMP9 proteinPMID:20424515 PMID:21042766 PMID:30130526
Mmp9decreases secretionISOMMP9 (Homo sapiens)6480464CTDPropranolol results in decreased secretion of MMP9 proteinPMID:20424515
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDDLL4 protein inhibits the reaction [Propranolol results in decreased expression of MMP9 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]; Propranolol inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]PMID:16574429 PMID:24929186 PMID:30130526
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