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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2350
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Acc ID: CHEBI:84500
Term: varenicline
Definition: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.
Chemical ID: MESH:D000068580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrnb2multiple interactionsEXP 6480464CTDVarenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:16766716
Chrnb2multiple interactionsISOCHRNB2 (Homo sapiens)6480464CTDVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:20207347 PMID:20331614 PMID:20373480 PMID:20388087
Chrnb2multiple interactionsISOChrnb2 (Mus musculus)6480464CTDVarenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:20100906
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