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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2346
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna4
Name: cholinergic receptor nicotinic alpha 4 subunit
Acc ID: CHEBI:84500
Term: varenicline
Definition: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.
Chemical ID: MESH:D000068580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna4multiple interactionsEXP 8549526RGDvarenicline binds to Chrna4 protein; varenicline inhibits [alpha-conotoxin MII binds to Chrna4 protein] in rat brain striatal sections 
Chrna4multiple interactionsEXP 6480464CTDVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:16766716
Chrna4multiple interactionsISOChrna4 (Mus musculus)6480464CTDVarenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:20100906
Chrna4multiple interactionsISOCHRNA4 (Homo sapiens)6480464CTDVarenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]PMID:20207347 PMID:20331614 PMID:20373480 PMID:20388087
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