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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr3
Name: toll-like receptor 3
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr3increases activityEXP 6480464CTDPoly I-C results in increased activity of TLR3 proteinPMID:24423102
Tlr3multiple interactionsEXP 6480464CTDMIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]PMID:24423102
Tlr3increases activityISOTLR3 (Homo sapiens)6480464CTDPoly I-C results in increased activity of TLR3 proteinPMID:21398612 PMID:26682054 PMID:28003376
Tlr3increases activityISOTlr3 (Mus musculus)6480464CTDPoly I-C results in increased activity of TLR3 proteinPMID:25780039
Tlr3increases expressionISOTLR3 (Homo sapiens)6480464CTDPoly I-C results in increased expression of TLR3 mRNAPMID:17669408 PMID:21418039 PMID:32244040
Tlr3increases expressionISOTlr3 (Mus musculus)6480464CTDPoly I-C results in increased expression of TLR3 mRNAPMID:18306459
Tlr3multiple interactionsISOTLR3 (Homo sapiens)6480464CTD[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-aminopyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 mRNA; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 protein; Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; Poly I-C binds to and results in increased activity of TLR3 protein; Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]PMID:16399790 PMID:18779317 PMID:21398612 PMID:23266719 PMID:23458896 PMID:27385120 PMID:30341573
Tlr3multiple interactionsISOTlr3 (Mus musculus)6480464CTDcinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA]PMID:18306459
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