GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tlr3 | increases activity | EXP | | 6480464 | CTD | Poly I-C results in increased activity of TLR3 protein | PMID:24423102 | Tlr3 | multiple interactions | EXP | | 6480464 | CTD | MIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] | PMID:24423102 | Tlr3 | increases activity | ISO | TLR3 (Homo sapiens) | 6480464 | CTD | Poly I-C results in increased activity of TLR3 protein | PMID:21398612 PMID:26682054 PMID:28003376 | Tlr3 | increases activity | ISO | Tlr3 (Mus musculus) | 6480464 | CTD | Poly I-C results in increased activity of TLR3 protein | PMID:25780039 | Tlr3 | increases expression | ISO | TLR3 (Homo sapiens) | 6480464 | CTD | Poly I-C results in increased expression of TLR3 mRNA | PMID:17669408 PMID:21418039 PMID:32244040 | Tlr3 | increases expression | ISO | Tlr3 (Mus musculus) | 6480464 | CTD | Poly I-C results in increased expression of TLR3 mRNA | PMID:18306459 | Tlr3 | multiple interactions | ISO | TLR3 (Homo sapiens) | 6480464 | CTD | [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-aminopyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 mRNA; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 protein; Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; Poly I-C binds to and results in increased activity of TLR3 protein; Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA] | PMID:16399790 PMID:18779317 PMID:21398612 PMID:23266719 PMID:23458896 PMID:27385120 PMID:30341573 | Tlr3 | multiple interactions | ISO | Tlr3 (Mus musculus) | 6480464 | CTD | cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA] | PMID:18306459 | |
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