Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:8405
Term: primaquine
Definition: An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Chemical ID: MESH:D011319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4affects metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein affects the metabolism of PrimaquinePMID:12920490
Cyp2d4increases metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein results in increased metabolism of PrimaquinePMID:19616568
Cyp2d4increases response to substanceISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein results in increased susceptibility to PrimaquinePMID:26477383
Cyp2d4multiple interactionsISOCYP2D6 (Homo sapiens)6480464CTD[CYP2D6 protein results in increased expression of HBG2 protein] which affects the susceptibility to PrimaquinePMID:19616568
Go Back to source page   Continue to Ontology report