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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:8405
Term: primaquine
Definition: An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Chemical ID: MESH:D011319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of PrimaquinePMID:12920490
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTDPrimaquine results in increased activity of CYP1A2 promoterPMID:18502397
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDPrimaquine results in increased expression of CYP1A2 mRNAPMID:12451431 PMID:12623754 PMID:17954527
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of PrimaquinePMID:19616568
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein results in increased expression of HBG2 protein] which affects the susceptibility to PrimaquinePMID:19616568
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