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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:8273
Term: plumbagin
Definition: A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.
Chemical ID: MESH:C014758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityEXP 6480464CTDplumbagin results in increased activity of CASP9 proteinPMID:34302802
Casp9decreases expressionISOCASP9 (Homo sapiens)6480464CTDplumbagin results in decreased expression of CASP9 proteinPMID:36336213
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDplumbagin results in increased activity of CASP9 proteinPMID:20576514
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDplumbagin results in increased expression of CASP9 mRNAPMID:36336213
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP9 protein]PMID:20576514
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