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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620897 Species: Rattus norvegicus RGD Object: Gene Symbol: Dusp1 Name: dual specificity phosphatase 1

Acc ID: CHEBI:8249 Term: piroxicam Definition: A benzothiazine that has formula C15H13N3O4S. CasRN: 36322-90-4 Chemical ID: MESH:D010894

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:732954	6480464	CTD	Piroxicam results in decreased expression of DUSP1 mRNA	PMID:21858171
multiple interactions	ISO	RGD:732954	6480464	CTD	Cisplatin promotes the reaction [Piroxicam results in decreased expression of DUSP1 mRNA]	PMID:21858171