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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736366 Species: Homo sapiens RGD Object: Gene Symbol: REN Name: renin

Acc ID: CHEBI:8214 Term: pindolol Definition: An indole which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol. CasRN: 13523-86-9 Chemical ID: MESH:D010869

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]	PMID:7104148
decreases activity	EXP		6480464	CTD	Pindolol results in decreased activity of REN protein	PMID:791319
decreases expression	EXP		6480464	CTD	Pindolol results in decreased expression of REN protein	PMID:973972