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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:81792
Term: flutolanil
Definition: A member of the class of benzamides, obtained by formal condensation of the carboxy group of 2-(trifluoromethyl)benzoic acid with the amino group of 3-(ispropyloxy)aniline. A fungicide used to control a range of pathogens especially Rhizoctonia spp. on rice, turf and other crops.
Chemical ID: MESH:C475882
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDflutolanil results in decreased expression of ESR1 proteinPMID:17904202
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDflutolanil binds to and results in increased activity of ESR1 proteinPMID:17904202
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