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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:81784
Term: triflumizole
Definition: A carboxamidine resulting from the formal condensation of the amino group of 4-chloro-2-(trifluoromethyl)aniline with the oxygen of the acetyl group of N-(propoxyacetyl)imidazole. A sterol demethylation inhibitor, it is used as a fungicide for the control of powdery mildew, scab and other diseases on a variety of crops.
Chemical ID: MESH:C053549
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDtriflumizol results in increased activity of PPARG proteinPMID:20143881
Ppargincreases activityISOPparg (Mus musculus)6480464CTDtriflumizol results in increased activity of PPARG proteinPMID:23086663
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDtriflumizol results in increased expression of PPARG mRNAPMID:23086663
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDtriflumizol binds to and results in increased activity of PPARG proteinPMID:33049310
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDtriflumizol binds to and results in increased activity of PPARG proteinPMID:33049310
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