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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:81582
Term: 2,4-dibromophenyl 2,4,5-tribromophenyl ether
Definition: A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, 5, 2', and 4' positions have been replaced by bromines.
Chemical ID: MESH:C477694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionEXP 6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of CYP1A2 mRNAPMID:22331496
Cyp1a2increases oxidationEXP 6480464CTDCYP1A2 protein results in increased oxidation of 2,2',4,4',5-brominated diphenyl etherPMID:21673328
Cyp1a2multiple interactionsEXP 6480464CTD[CYP1A2 protein results in increased oxidation of 2,2',4,4',5-brominated diphenyl ether] which results in increased abundance of 2,2',4,4',5-brominated diphenyl ether metabolitePMID:21673328
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of CYP1A2 mRNAPMID:19270788
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