GENE - CHEMICAL INTERACTIONS REPORT
RGD ID:
2459
Species:
Rattus norvegicus
RGD Object:
Gene
Symbol:
Cyp1a2
Name:
cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID:
CHEBI:81522
Term:
2,3,3',4,4',5-Hexachlorobiphenyl
Definition:
A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID:
MESH:C087667
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Cyp1a2 decreases activity EXP 6480464 CTD 2,3,3',4,4',5-hexachlorobiphenyl results in decreased activity of CYP1A2 protein PMID:15659567 Cyp1a2 decreases activity ISO CYP1A2 (Homo sapiens) 6480464 CTD 2,3,3',4,4',5-hexachlorobiphenyl results in decreased activity of CYP1A2 protein PMID:15659567 Cyp1a2 increases activity ISO Cyp1a2 (Mus musculus) 6480464 CTD 2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of CYP1A2 protein PMID:10986007 Cyp1a2 increases expression ISO Cyp1a2 (Mus musculus) 6480464 CTD 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A2 mRNA PMID:23674508 Cyp1a2 multiple interactions ISO CYP1A2 (Homo sapiens) 6480464 CTD 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] PMID:18493746 
