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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2469 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp2c11 Name: cytochrome P450, subfamily 2, polypeptide 11

Acc ID: CHEBI:8107 Term: phenytoin Definition: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5. CasRN: 57-41-0 Chemical ID: MESH:D010672

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 5' UTR polymorphism results in decreased metabolism of Phenytoin	PMID:11503012
multiple interactions	ISO	RGD:1317784	6480464	CTD	[Clozapine results in decreased activity of CYP2C9 protein] which results in increased susceptibility to Phenytoin	PMID:17961958
decreases hydroxylation	ISO	RGD:1317784	6480464	CTD	CYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin	PMID:16873909 PMID:9860067
decreases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin	PMID:10208645 PMID:14659971 PMID:11503012 PMID:11740344 PMID:11434505 PMID:16220110
increases hydroxylation	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased hydroxylation of Phenytoin	PMID:9860067 PMID:9110362 PMID:2025243 PMID:16873909
increases response to substance	ISO	RGD:1317784	6480464	CTD	CYP2C9 gene polymorphism results in increased susceptibility to Phenytoin	PMID:11740344
affects metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein affects the metabolism of Phenytoin	PMID:15855726
increases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased metabolism of Phenytoin	PMID:10208645 PMID:10510154 PMID:16220110 PMID:11234294 PMID:10850388 PMID:19715737 PMID:11668218 PMID:11740344
multiple interactions	ISO	RGD:1317784	6480464	CTD	NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]	PMID:14600250
increases expression	ISO	RGD:1317784	6480464	CTD	Phenytoin results in increased expression of CYP2C9 mRNA	PMID:14600250
increases metabolic processing	EXP		6480464	CTD	CYP2C9 protein results in increased metabolism of Phenytoin	PMID:15569425
decreases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin	PMID:11434505 PMID:11503012 PMID:11740344 PMID:14659971 PMID:16220110 PMID:10208645
increases hydroxylation	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased hydroxylation of Phenytoin	PMID:16873909 PMID:9110362 PMID:2025243 PMID:9860067
increases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased metabolism of Phenytoin	PMID:10208645 PMID:16220110 PMID:11234294 PMID:11740344 PMID:19715737 PMID:10850388 PMID:10510154 PMID:11668218
decreases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin	PMID:16220110 PMID:11740344 PMID:11434505 PMID:11503012 PMID:10208645 PMID:14659971
increases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased metabolism of Phenytoin	PMID:10510154 PMID:19715737 PMID:11740344 PMID:10208645 PMID:11668218 PMID:10850388 PMID:16220110 PMID:11234294
decreases hydroxylation	ISO	RGD:1317784	6480464	CTD	CYP2C9 gene polymorphism results in decreased hydroxylation of Phenytoin	PMID:9860067 PMID:16873909
increases hydroxylation	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased hydroxylation of Phenytoin	PMID:2025243 PMID:16873909 PMID:9860067 PMID:9110362
decreases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin	PMID:11740344 PMID:11503012 PMID:14659971 PMID:11434505 PMID:10208645 PMID:16220110
increases hydroxylation	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased hydroxylation of Phenytoin	PMID:9110362 PMID:9860067 PMID:2025243 PMID:16873909
increases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased metabolism of Phenytoin	PMID:11668218 PMID:10850388 PMID:10510154 PMID:19715737 PMID:11740344 PMID:16220110 PMID:10208645 PMID:11234294
decreases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 gene polymorphism results in decreased metabolism of Phenytoin	PMID:10208645 PMID:11434505 PMID:11503012 PMID:11740344 PMID:14659971 PMID:16220110
increases metabolic processing	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased metabolism of Phenytoin	PMID:10208645 PMID:10510154 PMID:10850388 PMID:11234294 PMID:11668218 PMID:11740344 PMID:16220110 PMID:19082874 PMID:19715737
increases hydroxylation	ISO	RGD:1317784	6480464	CTD	CYP2C9 protein results in increased hydroxylation of Phenytoin	PMID:16873909 PMID:2025243 PMID:9110362 PMID:9860067
increases activity	ISO	RGD:1317784	6480464	CTD	Phenytoin results in increased activity of CYP2C9 protein	PMID:19202563