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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730886 Species: Homo sapiens RGD Object: Gene Symbol: CREB1 Name: cAMP responsive element binding protein 1

Acc ID: CHEBI:8093 Term: phenylephrine Definition: A phenylethanolamine that has formula C9H13NO2. CasRN: 59-42-7 Chemical ID: MESH:D010656

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:620218	6480464	CTD	adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein] Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]	PMID:15522277
multiple interactions	ISO	RGD:620218	6480464	CTD	Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein	PMID:14741741 PMID:15522277
multiple interactions	ISO	RGD:620218	6480464	CTD	Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein	PMID:15522277 PMID:14741741