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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68394
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnd3
Name: potassium voltage-gated channel subfamily D member 3
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnd3decreases expressionEXP 6480464CTDPhenylephrine results in decreased expression of KCND3 mRNA; Phenylephrine results in decreased expression of KCND3 proteinPMID:11249870 PMID:16385079 PMID:17060317
Kcnd3multiple interactionsISOKCND3 (Homo sapiens)6480464CTD[KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]PMID:11709419
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