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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532 Species: Rattus norvegicus RGD Object: Gene Symbol: Edn1 Name: endothelin 1

Acc ID: CHEBI:8093 Term: phenylephrine Definition: A phenylethanolamine that has formula C9H13NO2. CasRN: 59-42-7 Chemical ID: MESH:D010656

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases response to substance	EXP		6480464	CTD	EDN1 protein results in increased susceptibility to Phenylephrine	PMID:20977430
multiple interactions	EXP		6480464	CTD	Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]	PMID:20977430
multiple interactions	ISO	RGD:730848	6480464	CTD	EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]	PMID:12724418
multiple interactions	EXP		6480464	CTD	Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]	PMID:10788492
increases expression	EXP		6480464	CTD	Phenylephrine results in increased expression of EDN1 mRNA	PMID:10788492
increases expression	EXP		6480464	CTD	Phenylephrine results in increased expression of EDN1 protein	PMID:15220332
multiple interactions	EXP		6480464	CTD	Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]	PMID:15007106
multiple interactions	EXP		6480464	CTD	Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]	PMID:11739382
multiple interactions	EXP		6480464	CTD	ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]	PMID:15220332