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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62219 Species: Mus musculus RGD Object: Gene Symbol: Gjb1 Name: gap junction protein, beta 1

Acc ID: CHEBI:8069 Term: phenobarbital Definition: Barbituric acid substituted at C-5 by ethyl and phenyl groups. CasRN: 50-06-6 Chemical ID: MESH:D010634

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects response to substance	EXP		6480464	CTD	GJB1 affects the susceptibility to Phenobarbital	PMID:11016633
increases response to substance	EXP		6480464	CTD	GJB1 protein results in increased susceptibility to Phenobarbital	PMID:18308698
multiple interactions	ISO	RGD:61926	6480464	CTD	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GJB1 protein [Ethylnitrosourea co-treated with Phenobarbital] results in decreased expression of GJB1 protein	PMID:1973356