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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxraaffects expressionEXP 6480464CTDPhenobarbital affects the expression of RXRA mRNAPMID:16510358
Rxraincreases expressionEXP 6480464CTDPhenobarbital results in increased expression of RXRA mRNAPMID:23273579
Rxramultiple interactionsISORxra (Mus musculus)6480464CTDNR1I3 gene mutant form inhibits the reaction [Phenobarbital promotes the reaction [RXRA protein binds to KCNK1 promoter]]; Phenobarbital promotes the reaction [RXRA protein binds to KCNK1 promoter]PMID:23291559
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