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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309970 Species: Rattus norvegicus RGD Object: Gene Symbol: Gsta4 Name: glutathione S-transferase alpha 4

Acc ID: CHEBI:8069 Term: phenobarbital Definition: Barbituric acid substituted at C-5 by ethyl and phenyl groups. CasRN: 50-06-6 Chemical ID: MESH:D010634

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1320602	6480464	CTD	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GSTA4 mRNA]	PMID:19482888
increases expression	ISO	RGD:1320602	6480464	CTD	Phenobarbital results in increased expression of GSTA4 mRNA	PMID:19482888 PMID:19270015
multiple interactions	EXP		6480464	CTD	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of GSTA4 protein	PMID:20935162
increases expression	EXP		6480464	CTD	Phenobarbital results in increased expression of GSTA4 mRNA	PMID:19162173
increases expression	ISO	RGD:1320602	6480464	CTD	Phenobarbital results in increased expression of GSTA4 mRNA	PMID:19270015 PMID:19482888 PMID:18723825
increases expression	ISO	RGD:1320602	6480464	CTD	Phenobarbital results in increased expression of GSTA4 mRNA	PMID:19482888 PMID:19270015 PMID:18723825
decreases expression	ISO	RGD:1320601	6480464	CTD	Phenobarbital results in decreased expression of GSTA4 mRNA	PMID:19084549
increases expression	ISO	RGD:1320602	6480464	CTD	Phenobarbital results in increased expression of GSTA4 mRNA	PMID:18723825 PMID:19482888 PMID:19270015
increases expression	ISO	RGD:1320602	6480464	CTD	Phenobarbital results in increased expression of GSTA4 mRNA	PMID:18723825 PMID:19270015 PMID:19482888