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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303321 Species: Rattus norvegicus RGD Object: Gene Symbol: Ier3 Name: immediate early response 3

Acc ID: CHEBI:8069 Term: phenobarbital Definition: Barbituric acid substituted at C-5 by ethyl and phenyl groups. CasRN: 50-06-6 Chemical ID: MESH:D010634

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1621625	6480464	CTD	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IER3 mRNA]	PMID:19482888
decreases expression	ISO	RGD:1621625	6480464	CTD	Phenobarbital results in decreased expression of IER3 mRNA	PMID:19270015
increases expression	ISO	RGD:1621625	6480464	CTD	Phenobarbital results in increased expression of IER3 mRNA	PMID:19482888
affects expression	ISO	RGD:1347080	6480464	CTD	Phenobarbital affects the expression of IER3 mRNA	PMID:19159669