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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:79516
Term: Nonylphenol
Definition: null
Chemical ID: MESH:C025256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionEXP 6480464CTDnonylphenol results in increased expression of PTGS2 proteinPMID:30481583 PMID:30629985
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDnonylphenol results in increased expression of PTGS2 mRNAPMID:20954072
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]; [nonylphenol results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; nonylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; nonylphenol results in increased expression of and results in increased activity of PTGS2 protein; SB 203580 inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]PMID:20954072 PMID:28168795
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