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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jund
Name: JunD proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:78886
Term: 2-tert-butylhydroquinone
Definition: A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
Chemical ID: MESH:C018855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundincreases phosphorylationISOJUND (Homo sapiens)6480464CTD2-tert-butylhydroquinone results in increased phosphorylation of JUND proteinPMID:24830941
Jundmultiple interactionsISOJUND (Homo sapiens)6480464CTD2-tert-butylhydroquinone promotes the reaction [JUND protein binds to CYP2C9 promoter]; 2-tert-butylhydroquinone promotes the reaction [JUND protein modified form binds to CYP2C9 promoter]; JUND mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]; pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of JUND protein]PMID:24830941
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