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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:78782
Term: pyrrolidine dithiocarbamate
Definition: A member of the class of dithiocarbamic acids that is the N-dithiocarboxy derivative of pyrrolidine.
Chemical ID: MESH:C020972
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53decreases expressionEXP 6480464CTDpyrrolidine dithiocarbamic acid results in decreased expression of TP53 proteinPMID:16049548
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTDpyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA]PMID:25559736
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[pyrrolidine dithiocarbamic acid results in increased abundance of Copper] which results in increased oxidation of and results in increased expression of TP53 protein; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid results in increased abundance of Copper] which results in increased oxidation of and results in increased expression of TP53 protein]; pyrrolidine dithiocarbamic acid results in increased oxidation of and results in increased expression of TP53 proteinPMID:11964141
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