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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3389
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaca
Name: protein kinase cAMP-activated catalytic subunit alpha
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkacadecreases phosphorylationEXP 6480464CTDOxidopamine results in decreased phosphorylation of PRKACA proteinPMID:16339297
Prkacamultiple interactionsEXP 6480464CTDClenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]; Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]; Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]PMID:16339297
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