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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2518
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd1
Name: dopamine receptor D1
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd1decreases expressionEXP 6480464CTDOxidopamine results in decreased expression of DRD1 mRNA; Oxidopamine results in decreased expression of DRD1 proteinPMID:16365282 PMID:18707801
Drd1increases expressionEXP 6480464CTDOxidopamine results in increased expression of DRD1 proteinPMID:19399396
Drd1multiple interactionsEXP 6480464CTD[Levodopa co-treated with Oxidopamine] results in increased expression of DRD1 mRNA; [Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein]; Levodopa inhibits the reaction [Oxidopamine results in decreased expression of DRD1 protein]PMID:16365282 PMID:19118628 PMID:19399396
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