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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:78671
Term: sodium chromate
Definition: An inorganic sodium salt consisting of sodium and chromate ions in a 2:1 ratio.
Chemical ID: MESH:C028982
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDsodium chromate(VI) results in increased expression of H2AX protein modified formPMID:28318385
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTDMUS81 protein mutant form inhibits the reaction [sodium chromate(VI) results in increased expression of H2AX protein modified form]PMID:28318385
H2axmultiple interactionsISOH2ax (Mus musculus)6480464CTD[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein]PMID:35643323
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