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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:78576
Term: aflatoxin M1
Definition: A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at position 9a is replaced by a hydroxy group.
Chemical ID: MESH:D016607
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDAflatoxin M1 results in increased activity of NR1I2 proteinPMID:21641981
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTDAflatoxin M1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]PMID:21641981
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