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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736217 Species: Homo sapiens RGD Object: Gene Symbol: CYP2D6 Name: cytochrome P450, family 2, subfamily D, polypeptide 6

Acc ID: CHEBI:7852 Term: oxycodone Definition: An organic heteropentacyclic compound that has formula C18H21NO4. CasRN: 76-42-6 Chemical ID: MESH:D010098

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects response to substance	EXP		6480464	CTD	CYP2D6 gene polymorphism affects the susceptibility to Oxycodone	PMID:20590588
multiple interactions	EXP		6480464	CTD	[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone	PMID:20590588