GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects localization | ISO | TP53 (Homo sapiens) | 6480464 | CTD | dorsomorphin affects the localization of TP53 protein | PMID:23274516 | Tp53 | increases response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 protein results in increased susceptibility to dorsomorphin | PMID:23274516 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Acetylcysteine inhibits the reaction [dorsomorphin results in increased expression of and results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of and results in increased phosphorylation of TP53 protein]; dorsomorphin inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; dorsomorphin results in increased phosphorylation of and results in increased expression of TP53 protein; TP53 mutant form inhibits the reaction [dorsomorphin results in decreased expression of CCNB1 protein]; TP53 mutant form inhibits the reaction [dorsomorphin results in decreased phosphorylation of and results in decreased expression of CDK1 protein]; TP53 mutant form inhibits the reaction [dorsomorphin results in increased cleavage of CASP3 protein]; TP53 mutant form inhibits the reaction [dorsomorphin results in increased cleavage of PARP1 protein]; TP53 mutant form inhibits the reaction [dorsomorphin results in increased expression of CDKN1A protein] | PMID:19020741 PMID:23274516 | | ||||||||||||||||||||||
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