Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1308542
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Sirt1
Name:	sirtuin 1

Acc ID:	CHEBI:78420
Term:	icariin
Definition:	A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).
Chemical ID:	MESH:C056599

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Sirt1	affects expression	EXP		6480464	CTD	icariin affects the expression of SIRT1 mRNA; icariin affects the expression of SIRT1 protein	PMID:25472572
Sirt1	increases expression	ISO	SIRT1 (Homo sapiens)	6480464	CTD	icariin results in increased expression of SIRT1 mRNA; icariin results in increased expression of SIRT1 protein	PMID:25472572
Sirt1	multiple interactions	ISO	SIRT1 (Homo sapiens)	6480464	CTD	icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]	PMID:25472572
Sirt1	multiple interactions	ISO	Sirt1 (Mus musculus)	6480464	CTD	icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]; icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]]	PMID:19303870

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