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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:77323
Term: ethoxyquin
Definition: A quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6.
Chemical ID: MESH:D005015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects activityISONfe2l2 (Mus musculus)6480464CTDEthoxyquin affects the activity of NFE2L2 proteinPMID:11309284
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein promotes the reaction [Ethoxyquin results in increased expression of AKR1B10 mRNA]PMID:21277289
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; Ethoxyquin binds to and results in increased activity of NFE2L2 proteinPMID:15833929 PMID:15919853
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