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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565825
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm4
Name: glutathione S-transferase mu 4
Acc ID: CHEBI:77319
Term: oltipraz
Definition: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
Chemical ID: MESH:C026209
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm4increases expressionISOGstm4 (Mus musculus)6480464CTDoltipraz results in increased expression of GSTM4 mRNAPMID:18723825 PMID:22496397
Gstm4multiple interactionsISOGstm4 (Mus musculus)6480464CTD[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM4 mRNA]PMID:22496397
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