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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:77260
Term: 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole
Definition: A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Chemical ID: MESH:D009853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityEXP 6480464CTDOmeprazole results in increased activity of NR1I2 proteinPMID:27732639
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDOmeprazole results in increased activity of NR1I2 proteinPMID:25680588 PMID:26187274
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]PMID:12695340 PMID:17041008
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