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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases expressionEXP 6480464CTDochratoxin A results in increased expression of PPARG mRNAPMID:15994020
Ppargmultiple interactionsEXP 6480464CTD15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA]PMID:15994020
Ppargdecreases activityISOPPARG (Homo sapiens)6480464CTDochratoxin A results in decreased activity of PPARG proteinPMID:20590410 PMID:27481073
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDochratoxin A results in decreased expression of PPARGPMID:20590410
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDochratoxin A results in increased expression of PPARG mRNAPMID:32905824
Ppargincreases phosphorylationISOPPARG (Homo sapiens)6480464CTDochratoxin A results in increased phosphorylation of PPARG proteinPMID:20590410
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