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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1increases expressionEXP 6480464CTDochratoxin A results in increased expression of CDK1 mRNA; ochratoxin A results in increased expression of CDK1 proteinPMID:19237604 PMID:19717638 PMID:24243707 PMID:30120945
Cdk1multiple interactionsEXP 6480464CTDSLC22A2 protein affects the reaction [ochratoxin A results in increased expression of CDK1 protein]PMID:30120945
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDochratoxin A results in decreased expression of CDK1 mRNA; ochratoxin A results in decreased expression of CDK1 protein; ochratoxin A results in decreased expression of CDK1 protein modified formPMID:20060447 PMID:22230261 PMID:30428381 PMID:36058351
Cdk1increases expressionISOCdk1 (Mus musculus)6480464CTDochratoxin A results in increased expression of CDK1 mRNAPMID:25636497
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]; 4-phenylbutyric acid inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]; [Citrinin co-treated with ochratoxin A] results in decreased expression of CDK1 mRNA; MAPK1 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]; MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]; MAPK14 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]; MAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]; ochratoxin A inhibits the reaction [CCNB1 protein binds to CDK1 protein]; ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]; SB 203580 inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]; SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]PMID:20060447 PMID:22230261 PMID:30428381 PMID:36058351
Cdk1multiple interactionsISOCdk1 (Mus musculus)6480464CTDTRP53 gene mutant form promotes the reaction [ochratoxin A results in increased expression of CDK1 mRNA]PMID:25636497
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